A novel high-throughput scanning microscope for label-free detection of protein and small-molecule chemical microarrays....
Published in Review of Scientific Instruments
We describe a novel scanning optical microscope based on a polarization-modulated nulling ellipsometry. The new microscope employs a combination of scanning mirror and sample translation and thus enables high-throughput label-free detection of biomolecular microarrays with more than 10 000 protein or small-molecule targets. For illustration, we sho...