Molecular mimics can induce a nonautoaggressive repertoire that preempts induction of autoimmunity
...Published in Proceedings of the National Academy of Sciences of the United States of America
To determine the role that competition plays in a molecular mimic’s capacity to induce autoimmunity, we studied the ability of naïve encephalitogenic T cells to expand in response to agonist altered peptide ligands (APLs), some capable of stimulating both self-directed and exclusively APL-specific T cells. Our results show that although the APLs ca...
