Kit Lam Lab - UC Davis
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Optimization of RGD-Containing Cyclic Peptides against αvβ3 Integrin.

Wang, Y Wenwu Xiao Zhang, Y Meza, L Tseng, H Takada, Y Ames, Jb Kit S. Lam

Published in Molecular Cancer Therapeutics

We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp-containing octapeptide LXW7 (cGRGDdvc), that targets αvβ3 integrin with high affinity and specificity. αvβ3 integrin is known to be overexpressed in many cancers and in tumor vasculature, and it has been establishe...

The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer tar...

Xiao, Wenwu Wang, Yan Lau, Edmond Y Luo, Juntao Yao, Nianhuan Shi, Changying Meza, Leah Tseng, Harry Maeda, Yoshiko Kumaresan, Pappanaicken ...

Published in Molecular cancer therapeutics

The αvβ3 integrin, expressed on the surface of various normal and cancer cells, is involved in numerous physiologic processes such as angiogenesis, apoptosis, and bone resorption. Because this integrin plays a key role in angiogenesis and metastasis of human tumors, αvβ3 integrin ligands are of great interest to advances in targeted therapy and can...

Novel peptide ligands for a4b1 integrin over-expressed in bronchiolalveolar cancer cells

Mikawa, M Wang, H Ruiwu (Ray) Liu Kit S. Lam Lau, Dh

Published in Molecular Cancer Therapeutics

Identification of novel targeting peptides for human ovarian cancer cells using "one-bead one-compound" combinatorial li...

Aina, Oh Marik, J Ruiwu (Ray) Liu Lau, Dh Kit S. Lam

Published in Molecular Cancer Therapeutics

Using "one-bead one-compound" combinatorial chemistry technology, we generated random peptide libraries containing millions of 90 mum TentaGel beads, each with its own unique amino acid sequence. A cyclic random 8-mer library was screened with CAOV-3 (a human ovarian adenocarcinoma cell line) and beads with a unique ligand that bind to the cell sur...

In vivo optical imaging of human lymphoma xenograft using a library-derived peptidomimetic against alpha4beta1 integrin....

Peng, L Ruiwu (Ray) Liu Andrei, M Wenwu Xiao Kit S. Lam

Published in Molecular Cancer Therapeutics

Increasing literature suggests that cell adhesion molecule alpha4beta1 integrin plays a pivotal role in autoimmune diseases and cancer development. Noninvasive visualization of alpha4beta1 integrin in vivo will facilitate the understanding of its involvement in disease progression and development of targeted therapies. Due to the lack of high-affin...

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