Wang, Y Wenwu Xiao Zhang, Y Meza, L Tseng, H Takada, Y Ames, Jb Kit S. Lam
Published in
Molecular Cancer Therapeutics
We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp-containing octapeptide LXW7 (cGRGDdvc), that targets αvβ3 integrin with high affinity and specificity. αvβ3 integrin is known to be overexpressed in many cancers and in tumor vasculature, and it has been establishe...
Xiao, Wenwu Wang, Yan Lau, Edmond Y Luo, Juntao Yao, Nianhuan Shi, Changying Meza, Leah Tseng, Harry Maeda, Yoshiko Kumaresan, Pappanaicken
...
Published in
Molecular cancer therapeutics
The αvβ3 integrin, expressed on the surface of various normal and cancer cells, is involved in numerous physiologic processes such as angiogenesis, apoptosis, and bone resorption. Because this integrin plays a key role in angiogenesis and metastasis of human tumors, αvβ3 integrin ligands are of great interest to advances in targeted therapy and can...
Mikawa, M Wang, H Ruiwu (Ray) Liu Kit S. Lam Lau, Dh
Published in
Molecular Cancer Therapeutics
Aina, Oh Marik, J Ruiwu (Ray) Liu Lau, Dh Kit S. Lam
Published in
Molecular Cancer Therapeutics
Using "one-bead one-compound" combinatorial chemistry technology, we generated random peptide libraries containing millions of 90 mum TentaGel beads, each with its own unique amino acid sequence. A cyclic random 8-mer library was screened with CAOV-3 (a human ovarian adenocarcinoma cell line) and beads with a unique ligand that bind to the cell sur...
Peng, L Ruiwu (Ray) Liu Andrei, M Wenwu Xiao Kit S. Lam
Published in
Molecular Cancer Therapeutics
Increasing literature suggests that cell adhesion molecule alpha4beta1 integrin plays a pivotal role in autoimmune diseases and cancer development. Noninvasive visualization of alpha4beta1 integrin in vivo will facilitate the understanding of its involvement in disease progression and development of targeted therapies. Due to the lack of high-affin...