Kit Lam Lab - UC Davis

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Development of hydrogel TentaGel shell-core beads for ultrahigh throughput solution-phase screening of encoded OBOC comb...

Hg, Baek R, Liu Ks, Lam

Published in Journal of Combinatorial Chemistry

The one-bead one-compound (OBOC) combinatorial library method enables the rapid generation and screening of millions of discrete chemical compounds on beads. Most of the OBOC screening methods require the library compounds to remain tethered to the bead during screening process. Methods have also been developed to release library compounds from imm...

Synthesis and reactions of 7-fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid: a novel scaffold for combi...

Song, A Zhang, J Kit S. Lam

Published in Journal of Combinatorial Chemistry

7-Fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid has been prepared as a novel scaffold for combinatorial synthesis of coumarins. The scaffold has three points of diversity. The optimal conditions for its reactions with different nucleophiles in solid phase were obtained. Sixteen coumarin derivatives with different structures were d...

Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ rel...

Townsend, Jb Shaheen, F Ruiwu (Ray) Liu Kit S. Lam

Published in Journal of Combinatorial Chemistry

A method to efficiently immobilize and partition large quantities of microbeads in an array format in microfabricated poly(dimethylsiloxane) (PDMS) cassette for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound (OBOC) combinatorial libraries is described. Commercially available Jeffamine triamine T...

Image subtraction approach to screening one-bead-one-compound combinatorial libraries with complex protein mixtures.

Lehman, A Gholami, S Hahn, M Kit S. Lam

Published in Journal of Combinatorial Chemistry

To screen one-bead-one-compound (OBOC) combinatorial bead libraries,(1) one generally uses tagged purified protein as the screening probe. Compound beads that interact with the purified protein are then identified, for example, via an enzyme-linked colorimetric assay, and isolated for structure determination. In this report, we demonstrate a rapid ...

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