Kit Lam Lab - UC Davis

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LAS0811: From Combinatorial Chemistry to Activation of Antioxidant Response Element PDF available through Get Fulltext Research

Zhu, Ming Baek, Hyounggee Liu, Ruiwu Song, Aimin Lam, Kit Lau, Derick

Published in Journal of Biomedicine and Biotechnology

The antioxidant response element (ARE) and its transcription factor, nuclear factor-erythroid 2 p45-related factor 2 (Nrf2), are potential targets for cancer chemoprevention. We sought to screen small molecules synthesized with combinatorial chemistry for activation of ARE. By high-throughput screening of 9400 small molecules from 10 combinatorial ...

Protein and Chemical Microarrays-Powerful Tools for Proteomics.

Xu, Q Kit S. Lam

Published in Journal of Biomedicine and Biotechnology

In the last few years, protein and chemical microarrays have emerged as two important tools in the field of proteomics. Specific proteins, antibodies, small molecule compounds, peptides, and carbohydrates can now be immobilized on solid surfaces to form high-density microarrays. Depending on their chemical nature, immobilization of these molecules ...

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