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Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase.

Published in Combinatorial Chemistry & High Throughput Screening

Using a combinatorial peptide library that is based on the one-bead one-peptide approach we identified 14 peptide substrates for the c-ABL protein tyrosine kinase, which define three distinct consensus sequence groups. This is distinct from many serine/threonine kinases, which often phosphorylate only one major consensus sequence. The three consens...

Immobilized OBOC combinatorial bead array to facilitate multiplicative screening.

Published in Combinatorial Chemistry & High Throughput Screening

One-bead-one-compound (OBOC) combinatorial library screening has been broadly utilized for the last two decades to identify small molecules, peptides or peptidomimetics targeting variable screening probes such as cell surface receptors, bacteria, protein kinases, phosphatases, proteases etc. In previous screening methods, library beads were suspend...

3-Nitro-tyrosine as an internal quencher of autofluorescence enhances the compatibility of fluorescence based screening ...

Published in Combinatorial Chemistry & High Throughput Screening