Xiao, Kai Li, Yuanpei Lee, Joyce S Gonik, Abby M Dong, Tiffany Fung, Gabriel Sanchez, Eduardo Xing, Li Cheng, Holland R Luo, Juntao
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Published in
Cancer research
Micellar nanoparticles based on linear polyethylene glycol (PEG) block dendritic cholic acids (CA) copolymers (telodendrimers), for the targeted delivery of chemotherapeutic drugs in the treatment of cancers, are reported. The micellar nanoparticles have been decorated with a high-affinity "OA02" peptide against α-3 integrin receptor to improve the...
Carpenter, Richard D Natarajan, Arutselvan Lau, Edmond Y Andrei, Mirela Solano, Danielle M Lightstone, Felice C Denardo, Sally J Lam, Kit S Kurth, Mark J
Published in
Cancer research
Integrin alpha(4)beta(1) is an attractive but poorly understood target for selective diagnosis and treatment of T-cell and B-cell lymphomas. This report focuses on the rapid microwave preparation, structure-activity relationships, and biological evaluation of medicinally pertinent benzimidazole heterocycles as integrin alpha(4)beta(1) antagonists. ...
