Kit Lam Lab - UC Davis

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"OA02" peptide facilitates the precise targeting of paclitaxel-loaded micellar nanoparticles to ovarian cancer in vivo. PDF available through Get Fulltext Research

Xiao, Kai Li, Yuanpei Lee, Joyce S Gonik, Abby M Dong, Tiffany Fung, Gabriel Sanchez, Eduardo Xing, Li Cheng, Holland R Luo, Juntao ...

Published in Cancer research

Micellar nanoparticles based on linear polyethylene glycol (PEG) block dendritic cholic acids (CA) copolymers (telodendrimers), for the targeted delivery of chemotherapeutic drugs in the treatment of cancers, are reported. The micellar nanoparticles have been decorated with a high-affinity "OA02" peptide against α-3 integrin receptor to improve the...

Halogenated benzimidazole carboxamides target integrin alpha4beta1 on T-cell and B-cell lymphomas. PDF available through Get Fulltext Research

Carpenter, Richard D Natarajan, Arutselvan Lau, Edmond Y Andrei, Mirela Solano, Danielle M Lightstone, Felice C Denardo, Sally J Lam, Kit S Kurth, Mark J

Published in Cancer research

Integrin alpha(4)beta(1) is an attractive but poorly understood target for selective diagnosis and treatment of T-cell and B-cell lymphomas. This report focuses on the rapid microwave preparation, structure-activity relationships, and biological evaluation of medicinally pertinent benzimidazole heterocycles as integrin alpha(4)beta(1) antagonists. ...

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