Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3.
...Published in Bioorganic & medicinal chemistry letters
Increased concentrations of secreted phospholipase A2 type IIA (sPLA2-IIA), have been found in the synovial fluid of patients with rheumatoid arthritis. It has been shown that sPLA2-IIA specifically binds to integrin αvβ3, and initiates a signaling pathway that leads to cell proliferation and inflammation. Therefore, the interaction between integri...
