Kit Lam Lab - UC Davis
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A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells

Kim, Tae-Hun Venugopal, Senthil K. Zhu, Ming Wang, Si-Si Lau, Derick Lam, Kit S. Clemens, Dahn L. Zern, Mark A.

Published in Biochemical and Biophysical Research Communications

One of the pathways by which alcohol induces hepatocyte apoptosis is via oxidative stress. We screened several chemically-synthesized small molecules and found LAS-0811, which inhibits oxidative stress. In this study, we elucidated its role in inhibiting alcohol-induced apoptosis in hepatocyte-like VL-17A cells. VL-17A cells were pre-incubated with...

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