Publications - Page 5/29 - Kit Lam Lab

An alpha4beta1 integrin antagonist decreases airway inflammation in ovalbumin-exposed mice.

Nj, Kenyon R, Liu Em, O Roark W, Huang L, Peng Ks, Lam

Published in European Journal of Pharmacology

Inhibition of the alpha4 subunit of both the alpha4beta1 and alpha4beta7 integrins has shown promise in decreasing airway inflammation and airway hyperresponsiveness in various animal models. We hypothesized that a novel, high-affinity alpha4beta1 antagonist (LLP2A) would decrease the migration of eosinophils to the lung and ameliorate the airway h...

Effect of fluorescently labeling protein probes on kinetics of protein-ligand reactions.

Sun, Y S Landry, J P Fei, Y Y Zhu, X D Luo, J T Wang, X B Lam, K S

Published in Langmuir : the ACS journal of surfaces and colloids

We studied the effect of fluorescently labeling proteins on protein-ligand reactions. Unlabeled ligands (streptavidin-binding peptides and rabbit immunoglobulin G (IgG) as antigen targets) are immobilized on epoxy-functionalized glass slides. Unlabeled and Cy3-labeled protein probes from the same batch (streptavidin and goat antibodies) subsequentl...

Glycoproteomic analyses of ovarian cancer cell lines and sera from ovarian cancer patients show distinct glycosylation c...

Li, Bensheng An, Hyun Joo Kirmiz, Crystal Lebrilla, Carlito B Lam, Kit S Miyamoto, Suzanne

Published in Journal of proteome research

Ovarian cancer is difficult to diagnose in women because symptoms of the disease are often not noticed until the disease has progressed to an advanced untreatable stage. Although a serum test, CA125, is currently available to assist with monitoring treatment of ovarian cancer, this test lacks the necessary specificity and sensitivity for early dete...

Near-infrared optical imaging in glioblastoma xenograft with ligand-targeting α3 integrin

Xiao, Wenwu Yao, Nianhuan Peng, Li Liu, Ruiwu Lam, Kit S.

Published in European Journal of Nuclear Medicine and Molecular Imaging

PurposePatients with glioblastoma usually have a very poor prognosis. Even with a combination of radiotherapy plus temozolomide, the median survival of these patients is only 14.6 months. New treatment approaches to this cancer are needed. Our purpose is to develop new cell surface-binding ligands for glioblastoma cells and use them as targeted ima...

CD22-Binding Peptides Derived from Anti-CD22 Ligand Blocking Antibodies Retain the Targeting and Cell Killing Properties...

Pearson, David O’Donnell, Robert T. Cerejo, Miguel McKnight, Hayes C. Wang, Xiaobing Mařik, Jan Lam, Kit S. Tuscano, Joseph M.

Published in International Journal of Peptide Research and Therapeutics

CD22 is a B-cell specific membrane glycoprotein that mediates homotypic and heterotypic cell adhesion; it also regulates B-cell receptor (BCR)-mediated signals. Monoclonal antibodies (mAb) directed at the ligand binding domain of CD22 initiate CD22-mediated signal transduction and apoptosis in B-cell lymphomas (NHL). Amino acid analysis of the comp...

A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells

Kim, Tae-Hun Venugopal, Senthil K. Zhu, Ming Wang, Si-Si Lau, Derick Lam, Kit S. Clemens, Dahn L. Zern, Mark A.

Published in Biochemical and Biophysical Research Communications

A novel high-throughput scanning microscope for label-free detection of protein and small-molecule chemical microarrays....

Fei, Y Y Landry, J P Sun, Y S Zhu, X D Luo, J T Wang, X B Lam, K S

Published in The Review of scientific instruments

We describe a novel scanning optical microscope based on a polarization-modulated nulling ellipsometry. The new microscope employs a combination of scanning mirror and sample translation and thus enables high-throughput label-free detection of biomolecular microarrays with more than 10 000 protein or small-molecule targets. For illustration, we sho...