Design Platforms of Nanocapsules for Human Therapeutics or Vaccines
Novel flavonoids with antiproliferative activities against breast cancer cells.
Published in Journal of medicinal chemistry
A series of flavone analogues were synthesized and evaluated for their antiproliferation activity against breast cancer cells. The IC(50) of compound 10 and 24 were determined to be at 5 μM. These compounds were used as baits to screen breast cancer cDNA expression phage display proteome library. DNA sequencing of the binding phages suggests that e...
Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation.
Published in Carbohydrate research
The synthesis of glycosylated Fmoc amino acids by reaction of mono- and disaccharide peracetates with Fmoc amino acids having free carboxyl groups was rapidly promoted by Lewis acids (SnCl(4), BF(3)·Et(2)O) under microwave irradiation. The products are useful building blocks for the synthesis of glycopeptides. Copyright © 2010 Elsevier Ltd. All rig...
The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer tar...
...Published in Molecular cancer therapeutics
The αvβ3 integrin, expressed on the surface of various normal and cancer cells, is involved in numerous physiologic processes such as angiogenesis, apoptosis, and bone resorption. Because this integrin plays a key role in angiogenesis and metastasis of human tumors, αvβ3 integrin ligands are of great interest to advances in targeted therapy and can...
Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment.
...Published in Bioconjugate chemistry
We have developed a well-defined and biocompatible amphiphilic telodendrimer system (PEG-b-dendritic oligo-cholic acid) which can self-assemble into multifunctional micelles in aqueous solution for efficient delivery of hydrophobic drugs such as paclitaxel. In this telodendrimer system, cholic acid is essential for the formation of stable micelles ...
Halogenated benzimidazole carboxamides target integrin alpha4beta1 on T-cell and B-cell lymphomas.
Published in Cancer research
Integrin alpha(4)beta(1) is an attractive but poorly understood target for selective diagnosis and treatment of T-cell and B-cell lymphomas. This report focuses on the rapid microwave preparation, structure-activity relationships, and biological evaluation of medicinally pertinent benzimidazole heterocycles as integrin alpha(4)beta(1) antagonists. ...
A novel size-tunable nanocarrier system for targeted anticancer drug delivery.
Published in Journal of Controlled Release
We have developed a nanocarrier drug-delivery system based on micelles formed by a new class of well-defined linear PEGylated two-arm oligomer of cholic acids in aqueous solution. By varying the length of the linear PEG chains and the configuration of cholic acid oligomer, one can easily fine-tune the physicochemical properties of the amphiphilic p...
Molecular mimics can induce a nonautoaggressive repertoire that preempts induction of autoimmunity
...Published in Proceedings of the National Academy of Sciences of the United States of America
To determine the role that competition plays in a molecular mimic’s capacity to induce autoimmunity, we studied the ability of naïve encephalitogenic T cells to expand in response to agonist altered peptide ligands (APLs), some capable of stimulating both self-directed and exclusively APL-specific T cells. Our results show that although the APLs ca...
Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors.
...Published in Genes & cancer
There is overwhelming evidence that tyrosine kinases play an important role in cancer development. As a prototype of targeted therapy, tyrosine kinase inhibitors are now successfully applied to cancer treatment. However, as single agents, tyrosine kinase inhibitors have not achieved satisfactory results in the treatment of prostate cancer, principa...
3-Nitro-tyrosine as an internal quencher of autofluorescence enhances the compatibility of fluorescence based screening ...
Published in Combinatorial Chemistry & High Throughput Screening
