Kit Lam Lab - UC Davis
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1 News 315 Publications 13 Members

Jeffamine derivatized TentaGel beads and poly(dimethylsiloxane) microbead cassettes for ultrahigh-throughput in situ rel...

Townsend, Jb Shaheen, F Ruiwu (Ray) Liu Kit S. Lam

Published in Journal of Combinatorial Chemistry

A method to efficiently immobilize and partition large quantities of microbeads in an array format in microfabricated poly(dimethylsiloxane) (PDMS) cassette for ultrahigh-throughput in situ releasable solution-phase cell-based screening of one-bead-one-compound (OBOC) combinatorial libraries is described. Commercially available Jeffamine triamine T...

Application of the "libraries from libraries" concept to "one-bead one-compound" combinatorial chemistry.

Kappel, Jc Fan, Yc Kit S. Lam

Published in Advances in experimental medicine and biology

Selective phosphorylation of a nuclear envelope polypeptide by an endogenous protein kinase.

Kit S. Lam Kasper, Cb

Published in Biochemistry

Novel poly(ethylene-co-acrylic acid) nanofibrous biomaterials for peptide synthesis and biomedical applications.

Xiang, B Sun, G Kit S. Lam Kai Xiao

Published in Journal of Biomedical Materials Research Part A

Poly(ethylene-co-acrylic acid) (PE-co-AA) fibers in sizes of 200-500 nm were prepared by using a novel melt-extrusion-extraction fabrication process. The thermoplastic nanofibers could be controllably dispersed and reassembled by a novel solvent exchange filtration method. The dispersed PE-co-AA nanofibers possess active surface areas and could dir...

Synthesis and Characterization of a Novel Inhibitor of C-Reactive Protein–Mediated Proinflammatory Effects

Pappanaicken Kumaresan Devaraj, Sridevi Huang, Wenzhe Lau, Edmond Y. Ruiwu (Ray) Liu Kit S. Lam Jialal, Ishwarlal

Published in Metabolic Syndrome and Related Disorders

Image subtraction approach to screening one-bead-one-compound combinatorial libraries with complex protein mixtures.

Lehman, A Gholami, S Hahn, M Kit S. Lam

Published in Journal of Combinatorial Chemistry

To screen one-bead-one-compound (OBOC) combinatorial bead libraries,(1) one generally uses tagged purified protein as the screening probe. Compound beads that interact with the purified protein are then identified, for example, via an enzyme-linked colorimetric assay, and isolated for structure determination. In this report, we demonstrate a rapid ...

The "One-Bead-One-Compound" Combinatorial Library Method.

Kit S. Lam Lebl, M Krchnák, V

Published in Chemical Reviews

Reversing bone loss by directing mesenchymal stem cells to bone.

Yao, W Guan, M Jia, J Dai, W Lay, Ya Amugongo, S Ruiwu (Ray) Liu David John Olivos Mary Saunders Kit S. Lam ...

Published in Stem Cells

Bone regeneration by systemic transplantation of mesenchymal stem cells (MSCs) is problematic due to the inability to control the MSCs commitment, growth, and differentiation into functional osteoblasts on the bone surface. Our research group has developed a method to direct the MSCs to the bone surface by conjugating a synthetic peptidomimetic li...

Microfluidic-Enabled Print-to-Screen Platform for High-Throughput Screening of Combinatorial Chemotherapy.

Ding, Y Li, J Wenwu Xiao Kai Xiao Lee, J Urvashi Bhardwaj Zhu, Z Digiglio, P Yang, G Kit S. Lam ...

Published in Analytical Chemistry

Since the 1960s, combination chemotherapy has been widely utilized as a standard method to treat cancer. However, because of the potentially enormous number of drug candidates and combinations, conventional identification methods of the effective drug combinations are usually associated with significantly high operational costs, low throughput scre...

From combinatorial chemistry to cancer-targeting peptides.

Aina, Oh Ruiwu (Ray) Liu Sutcliffe, Jl Marik, J Pan, Cx Kit S. Lam

Published in Molecular Pharmaceutics

Several monoclonal antibodies that target cell surface receptors have gained approval by the U.S. Food and Drug Administration and are widely used in the treatment of some cancers. These include but are not limited to the anti-CD20 antibody Rituximab, used in lymphoma treatment, as well as anti-HER-2 antibody for breast cancer therapy. The efficacy...

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