Kit Lam Lab - UC Davis
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1 News 315 Publications 13 Members

Perspectives on clinical translation of smart nanotherapeutics

Lee, Joyce Kit S. Lam

Published in Therapeutic Delivery

Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kina...

Kit S. Lam Wu, J Lou, Q

Published in International journal of peptide & protein research

Using a random combinatorial peptide library method [Wu, J., Ma, Q. N. & Lam, K. S. (1994) Biochemistry 33, 14825-14833] a novel peptide, YIYGSFK, was identified as a substrate for p60c-src protein tyrosine kinase. Mass spectrometric analysis showed that tyrosine-3 from the N-terminus was the phosphorylation site. Kinetic studies showed that the Km...

Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies.

Leung, Ps Quan, C Park, O Van De Water, J Kurth, Mj Nantz, Mh Ansari, Aa Coppel, Rl Kit S. Lam Gershwin, Me ...

Published in The Journal of Immunology

The E2 subunit of pyruvate dehydrogenase complex (PDC-E2) is the major autoantigen recognized by antimitochondrial Abs (AMA) in primary biliary cirrhosis (PBC). Recently, we replaced the lipoic acid moiety of PDC-E2 with a battery of synthetic structures designed to mimic a xenobiotically modified lipoyl hapten on a 12-aa peptide that was found wit...

Identification of novel targeting peptides for human ovarian cancer cells using "one-bead one-compound" combinatorial li...

Aina, Oh Marik, J Ruiwu (Ray) Liu Lau, Dh Kit S. Lam

Published in Molecular Cancer Therapeutics

Using "one-bead one-compound" combinatorial chemistry technology, we generated random peptide libraries containing millions of 90 mum TentaGel beads, each with its own unique amino acid sequence. A cyclic random 8-mer library was screened with CAOV-3 (a human ovarian adenocarcinoma cell line) and beads with a unique ligand that bind to the cell sur...

Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analog...

Hong, Hs Maezawa, I Yao, N Xu, B Diaz-Avalos, R Rana, S Hua, Dh Cheng, Rh Kit S. Lam Jin, Lw ...

Published in Brain Research

The discovery of small molecule inhibitors of cytotoxicity induced by amyloid-beta (Abeta) oligomers, either applied extracellularly or accumulated intraneuronally, is an important goal of drug development for Alzheimer s disease (AD), but has been limited by the lack of efficient screening methods. Here we describe our approach using two cell-base...

Combinatorial peptide library methods for immunobiology research.

Ruiwu (Ray) Liu Enstrom, Am Kit S. Lam

Published in Experimental Hematology

The field of combinatorial peptide chemistry has emerged as a powerful tool in the study of many biological systems. This review focuses on combinatorial peptide library methodology, which includes biological library methods, spatially addressable parallel library methods, library methods requiring deconvolution, the "one-bead one-compound" library...

Microwave assisted DIC-promoted intramolecular cyclization for solid phase synthesis of trisubstituted imidazolidinones ...

Yao, Nianhuan Kurth, Mark J. Kit S. Lam Wang, Xiaobing Dixon, Seth

Published in Tetrahedron Letters

Traceless solid-phase synthesis of 1,4-disubstituted-6-nitro-3,4-dihydro-1H-quinoline-2-ones

Wang, Xiaobing Dixon, Seth Kurth, Mark J. Kit S. Lam

Published in Tetrahedron Letters

A serum glycomics approach to breast cancer biomarkers.

Kirmiz, C Li, B An, Hj Clowers, Bh Chew, Hk Kit S. Lam Ferrige, A Alecio, R Borowsky, Ad Sulaimon, S ...

Published in Molecular & Cellular Proteomics

Because the glycosylation of proteins is known to change in tumor cells during the development of breast cancer, a glycomics approach is used here to find relevant biomarkers of breast cancer. These glycosylation changes are known to correlate with increasing tumor burden and poor prognosis. Current antibody-based immunochemical tests for cancer bi...

Molecular imaging of very late antigen-4 (α4β1 integrin) in the premetastatic niche.

Shokeen, M Zheleznyak, A Wilson, Jm Jiang, M Ruiwu (Ray) Liu Ferdani, R Kit S. Lam Schwarz, Jk Anderson, Cj

Published in Journal of Nuclear Medicine

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