Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass
...Published in Nature Medicine
Synthesis and reactions of 7-fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid: a novel scaffold for combi...
Published in Journal of Combinatorial Chemistry
7-Fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid has been prepared as a novel scaffold for combinatorial synthesis of coumarins. The scaffold has three points of diversity. The optimal conditions for its reactions with different nucleophiles in solid phase were obtained. Sixteen coumarin derivatives with different structures were d...
A Novel encoding method for one-bead one-compound peptidomimetic and small molecule combinatorial libraries
Evaluation of ketone-oxime method for developing therapeutic on-demand cleavable immunoconjugates.
Published in Bioconjugate Chemistry
The use of antibody molecules in immunoassay, molecular targeting, or detection techniques encompasses a broad variety of applications affecting nearly every field of medical science. In cancer therapy, monoclonal antibodies (mAb) have been used as vehicles to deliver radionuclides, toxins, or drugs to the target cancer cells. New conjugation metho...
A novel and rapid encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial li...
Published in Journal of the American Chemical Society
A novel and efficient encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial libraries has been developed. The topologically segregated bifunctional resin beads with orthogonal protecting groups in the outer and inner regions are first prepared according to our previously published procedure. Prior to li...
Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation.
Published in PLoS ONE
Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects. We have previously developed a well-defined non-toxic PEG-dendritic block telodendrimer for successful delivery o...
Canine malignant melanoma alpha-3 integrin binding peptides
Published in Veterinary Immunology and Immunopathology
Molecular cloning, expression and mutagenesis of an anti-insulin single chain Fv (scFv).
Published in Molecular Immunology
The immunoglobulin variable region genes of a murine anti-insulin IgG-producing hybridoma were rescued and cloned into a bacterial expression vector. The variable regions of the gamma heavy chain and the kappa light chain were expressed independently and together as a single chain antibody (scFv). The variable heavy chain alone demonstrated the abi...
From combinatorial chemistry to chemical microarray.
Published in Current Opinion in Chemical Biology
Combinatorial chemistry was first applied to the generation of peptide arrays in 1984. Since then, the field of combinatorial chemistry has evolved rapidly into a new discipline. There is a great need for the development of methods to examine the proteome functionally at a global level. Using many of the techniques and instruments developed for DNA...
Design, synthesis, screening, and decoding of encoded one-bead one-compound peptidomimetic and small molecule combinator...
Published in G Protein Coupled Receptors - Structure
