Kit Lam Lab - UC Davis
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A Novel encoding method for one-bead one-compound peptidomimetic and small molecule combinatorial libraries

Song, A Zhang, J Lebrilla, Cb Kit S. Lam

A novel and rapid encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial li...

Song, A Zhang, J Lebrilla, Cb Kit S. Lam

Published in Journal of the American Chemical Society

A novel and efficient encoding method based on mass spectrometry for "one-bead-one-compound" small molecule combinatorial libraries has been developed. The topologically segregated bifunctional resin beads with orthogonal protecting groups in the outer and inner regions are first prepared according to our previously published procedure. Prior to li...

Synthesis and reactions of 7-fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid: a novel scaffold for combi...

Song, A Zhang, J Kit S. Lam

Published in Journal of Combinatorial Chemistry

7-Fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic acid has been prepared as a novel scaffold for combinatorial synthesis of coumarins. The scaffold has three points of diversity. The optimal conditions for its reactions with different nucleophiles in solid phase were obtained. Sixteen coumarin derivatives with different structures were d...

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation.

Kenyon, Nj Bratt, Jm Lee, J Luo, J Franzi, Lm Zeki, Aa Kit S. Lam

Published in PLoS ONE

Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects. We have previously developed a well-defined non-toxic PEG-dendritic block telodendrimer for successful delivery o...

Canine malignant melanoma alpha-3 integrin binding peptides

Aina, Olulanu H. Maeda, Yoshiko Harrison, Matthew Zwingenberger, Allison L. Walker, Naomi J. Kit S. Lam Kent, Michael S.

Published in Veterinary Immunology and Immunopathology

Molecular cloning, expression and mutagenesis of an anti-insulin single chain Fv (scFv).

Lake, Df Kit S. Lam Peng, L Hersh, Em

Published in Molecular Immunology

The immunoglobulin variable region genes of a murine anti-insulin IgG-producing hybridoma were rescued and cloned into a bacterial expression vector. The variable regions of the gamma heavy chain and the kappa light chain were expressed independently and together as a single chain antibody (scFv). The variable heavy chain alone demonstrated the abi...

From combinatorial chemistry to chemical microarray.

Kit S. Lam Renil, M

Published in Current Opinion in Chemical Biology

Combinatorial chemistry was first applied to the generation of peptide arrays in 1984. Since then, the field of combinatorial chemistry has evolved rapidly into a new discipline. There is a great need for the development of methods to examine the proteome functionally at a global level. Using many of the techniques and instruments developed for DNA...

Design, synthesis, screening, and decoding of encoded one-bead one-compound peptidomimetic and small molecule combinator...

Ruiwu (Ray) Liu Marik, J Kit S. Lam

Published in G Protein Coupled Receptors - Structure

The minimum element of a synthetic peptide required to block prostate tumor cell migration.

Sroka, Tc Marik, J Pennington, Me Kit S. Lam Cress, Ae

Published in Cancer Biology & Therapy

Human prostate tumor cell invasion and metastasis are dependent in part on cell adhesion to extracellular matrix proteins and cell migration. We previously identified a synthetic D-amino acid tumor cell adhesion peptide called HYD1 (kikmviswkg) that supported adhesion of tumor cells derived from breast, prostate, ovary and pancreas tissue. Alanine ...

Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing b...

Moritoki, Y Tsuneyama, K Kurth, Mj Kit S. Lam Yoshida, K Yang, Gx Hibi, T Ansari, Aa Ridgway, Wm Coppel, Rl ...

Published in Hepatology

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