Kit Lam Lab - UC Davis
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1 News 315 Publications 13 Members

Covalent Chemical Ligation Strategy for Mono- and Polyclonal Immunoglobulins at Their Nucleotide Binding Sites.

Lac, Diana Feng, Chun Bhardwaj, Gaurav Le, Huong Tran, Jimmy Xing, Li Fung, Gabriel Liu, Ruiwu Cheng, Holland Lam, Kit S ...

Published in Bioconjugate chemistry

Nonspecific ligation methods have been traditionally used to chemically modify immunoglobulins. Site-specific ligation of compounds (toxins or ligands) to antibodies has become increasingly important in the fields of therapeutic antibody-drug conjugates and bispecific antibodies. In this present study, we took advantage of the reported nucleotide-b...

Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a ne...

Fujita, Masaaki Zhu, Kan Fujita, Chitose K Zhao, Min Lam, Kit S Kurth, Mark J Takada, Yoko K Takada, Yoshikazu

Published in The Journal of biological chemistry

Integrins are activated by signaling from inside the cell (inside-out signaling) through global conformational changes of integrins. We recently discovered that fractalkine activates integrins in the absence of CX3CR1 through the direct binding of fractalkine to a ligand-binding site in the integrin headpiece (site 2) that is distinct from the clas...

3D plasmonic nanobowl platform for the study of exosomes in solution.

Lee, Changwon Carney, Randy P Hazari, Sidhartha Smith, Zachary J Knudson, Alisha Robertson, Christopher S Lam, Kit S Wachsmann-Hogiu, Sebastian

Published in Nanoscale

Thin silver film coated nanobowl Surface Enhanced Raman Spectroscopy (SERS) substrates are used to capture exosomes in solution for SERS measurements that can provide biochemical analysis of intact and ruptured exosomes. Exosomes derived via Total Exosome Isolation Reagent (TEIR) as well as ultracentrifugation (UC) from the SKOV3 cell line were ana...

Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor.

Guo, W Liu, R Bhardwaj, G Yang, J C Changou, C Ma, A-H Mazloom, A Chintapalli, S Xiao, K Xiao, W ...

Published in Cell death & disease

Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancies. Etk has been shown previously to provide a strong survival and metastasis signal in human prostate cancer cells, and to confer androgen independenc...

A smart and versatile theranostic nanomedicine platform based on nanoporphyrin.

Li, Yuanpei Lin, Tzu-Yin Luo, Yan Liu, Qiangqiang Xiao, Wenwu Guo, Wenchang Lac, Diana Zhang, Hongyong Feng, Caihong Wachsmann-Hogiu, Sebastian ...

Published in Nature communications

Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one...

MXD3 regulation of DAOY cell proliferation dictated by time course of activation

Ngo, Tin Barisone, Gustavo A Lam, Kit S Dίaz, Elva

Published in BMC Cell Biology

BackgroundMXD3 is a basic-helix-loop-helix-leucine-zipper transcription factor involved in cellular proliferation. In previous studies we demonstrated that knock-down of MXD3 in the human medulloblastoma cell line DAOY resulted in decreased proliferation. Surprisingly, overexpression of MXD3 in DAOY cells also decreased proliferation and increased ...

A structure-property relationship study of the well-defined telodendrimers to improve hemocompatibility of nanocarriers ...

Shi, Changying Yuan, Dekai Nangia, Shikha Xu, Gaofei Lam, Kit S Luo, Juntao

Published in Langmuir : the ACS journal of surfaces and colloids

A series of telodendrimer (a linear polyethyelene glycol-block-dendritic oligo-cholic acid) have been synthesized via a bottom-up approach to optimize the hemocompatibility of the nanocarrier. Numbers of hydrophilic glycerol groups were introduced onto the polar surface of cholic acid to reduce the plasma membrane lytic activity of telodendrimers. ...

Nanomicelle formulation modifies the pharmacokinetic profiles and cardiac toxicity of daunorubicin.

Zhang, Hongyong Li, Yuanpei Lin, Tzu-Yin Xiao, Kai Haddad, Ashraf S Henderson, Paul T Jonas, Brian A Chen, Mingyi Xiao, Wenwu Liu, Ruiwu ...

Published in Nanomedicine (London, England)

Treatment with daunorubicin (DNR) in acute myeloid leukemia is moderately effective and associated with significant side effects, including cardiac toxicity. We recently developed a nanomicellar formulation of DNR that specifically targets acute myeloid leukemia stem cells. Pharmacokinetics analysis of free DNR, DNR in nanomicellar formulations was...

Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers

Li, Yuanpei Xiao, Kai Zhu, Wei Deng, Wenbin Lam, Kit S.

Published in Advanced Drug Delivery Reviews

Schematic illustration of stimuli-responsive cross-linked micelles (SCMs) for cancer therapy.

Detection of formation and disintegration of micelles by oblique-incidence reflectivity difference microscopy

Sun, Ys Luo, J Kit S. Lam Zhu, Xd

Published in Instrumentation Science & Technology

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