About the Kit Lam Lab
The Lam Lab at UC Davis looks to the molecular and nanoscale world to develop innovative methods of treating disease. Their nanoparticle-based platform holds great potential for increasing the efficacy of drugs, while also reducing undesirable side effects. The method could find applications for multiple diseases and has been successful in treating ovarian, breast, prostate and bladder cancer, multiple myeloma and lymphoma in animal models. The Lam Lab’s nanoparticles could also be used as contrast agents for important medical imaging methods, like PET, MRI and CT scans.
The research group led by Dr. Kit Lam developed, in 1991, the technology that makes their current work possible. Called OBOC, for “one bead, one compound”, it allows a single, unique compound to be displayed per bead. This makes the generation and screening of millions of compounds possible within just a few days.
The original publication of the OBOC method:
Lam KS, Salmon SE, Hersh EM, Hruby V, Kazmierski WM, Knapp RJ: A new type of synthetic peptide library for identifying ligand-binding activity. Nature 354(7):82-84, 1991.
More information can be found on the lab’s website: https://basicscience.ucdmc.ucdavis.edu/Lam_Lab/
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